在一个肃杀的夜晚，满身伤痕的女孩西恩娜（艾丽森·兰格 Allison Lange 饰）跌跌撞撞冲入公路。她随即被送往医院，在探员赞恩（詹森·伦敦 Jason London 饰）的询问下，惊魂未定的西恩娜终于说出了那段恐怖经历。
　　两周前，她和同在医科大学念书的好友斯科特（B.J. Britt 饰）、杰森（尼克·霍尔莫斯 Nick Holmes 饰）、本（C.J. Thomason 饰）、夏侬等人结伴外出游玩。他们驻留在一所古堡，看似一切充满了刺激和乐趣，但是这份无上喜悦很快便蒙上一层阴影。在他们身后，似乎有一个手执手术刀的夺命医生蠢蠢欲动，死神的脚步越来越近。这群踌躇满志的未来医生，俨然成为了手术台上的致命牺牲品…

A group of diverse individuals are suddenly taken from their homes and flown via helicopter to a futuristic bomb shelter in the desert, one-third of a mile below the surface of the Earth. There, they learn that a nuclear holocaust is taking place and that they've been "chosen" by computer to survive in the shelter in order to continue the human race. The shelter is designed to ...